Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology

Tonio Oumeraci; Bernd Schmidt; Thomas Wolf; Marc Zapatka; Andreas Pich; Benedikt Brors; Roland Eils; Michael Fleischhacker; Brigitte Schlegelberger; Nils von Neuhoff

doi:10.1016/j.lungcan.2011.01.015

Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology

Lung Cancer. 2011 Apr;72(1):136-8. doi: 10.1016/j.lungcan.2011.01.015. Epub 2011 Feb 18.

Authors

Tonio Oumeraci, Bernd Schmidt, Thomas Wolf, Marc Zapatka, Andreas Pich, Benedikt Brors, Roland Eils, Michael Fleischhacker, Brigitte Schlegelberger, Nils von Neuhoff

PMID: 21334092
DOI: 10.1016/j.lungcan.2011.01.015

Abstract

The search for proteome-level markers of non-small cell lung cancer (NSCLC) has been mainly limited to serum or cell line screening approaches up to this point. We would like to demonstrate by this proof-of-principle study investigating bronchoalveolar lavage fluid samples from a cohort of NSCLC and control patients, that this readily available biofluid might be a more suitable source for discovering clinically usable NSCLC biomarkers.

Publication types

Letter

MeSH terms

Biomarkers, Tumor / metabolism
Bronchoalveolar Lavage Fluid*
Carcinoma, Non-Small-Cell Lung / diagnosis*
Humans
Lung Neoplasms / diagnosis*
Mass Spectrometry
Proteomics*

Substances

Biomarkers, Tumor