[HTML][HTML] Critical roles of PTPN family members regulated by non-coding RNAs in tumorigenesis and immunotherapy
X Tang, C Qi, H Zhou, Y Liu - Frontiers in oncology, 2022 - frontiersin.org
Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation state
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …
[HTML][HTML] Consideration of SHP-1 as a Molecular Target for Tumor Therapy
S Lim, KW Lee, JY Kim, KD Kim - International Journal of Molecular …, 2023 - mdpi.com
Abnormal activation of receptor tyrosine kinases (RTKs) contributes to tumorigenesis, while
protein tyrosine phosphatases (PTPs) contribute to tumor control. One of the most …
protein tyrosine phosphatases (PTPs) contribute to tumor control. One of the most …
[HTML][HTML] Expression of CD22 in triple-negative breast cancer: a novel prognostic biomarker and potential target for CAR therapy
T Zaib, K Cheng, T Liu, R Mei, Q Liu, X Zhou… - International Journal of …, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) accounts for 15–20% of all breast cancer cases. Due
to the lack of expression of well-known molecular targets [estrogen receptor (ER) …
to the lack of expression of well-known molecular targets [estrogen receptor (ER) …
Antagonizing roles of SHP1 in the pathogenesis of Helicobacter pylori infection
S Chen, H Zhao, Y Tian, Q Wu, J Zhang, S Liu… - …, 2024 - Wiley Online Library
Background SHP1 has been documented as a tumor suppressor and it was thought to play
an antagonistic role in the pathogenesis of Helicobacter pylori infection. In this study, the …
an antagonistic role in the pathogenesis of Helicobacter pylori infection. In this study, the …
[HTML][HTML] Synthesis and Biological Evaluation of 3-Amino-4, 4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators
H Chen, Z Liu, L Gao, LF Yu, Y Zhou, J Tang, J Li… - Molecules, 2023 - mdpi.com
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor
member of the protein tyrosine phosphatase (PTP) family, negatively regulates several …
member of the protein tyrosine phosphatase (PTP) family, negatively regulates several …
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis
S Qiao, T Wang, H Wang - Medical Oncology, 2023 - Springer
Breast cancer is a prevalent malignant tumor, posing a significant threat to women's health
globally due to its increasing incidence and tendency to affect younger patients. Protein …
globally due to its increasing incidence and tendency to affect younger patients. Protein …
[HTML][HTML] Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases
A Wang, Y Zhang, X Lv, G Liang - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Protein tyrosine phosphorylation is a post-translational modification that regulates protein
structure to modulate demic organisms' homeostasis and function. This physiological …
structure to modulate demic organisms' homeostasis and function. This physiological …
OPEN ACCESS EDITED BY
Protein tyrosine phosphatases (PTPs) are a wide class of enzymes that oppose protein
tyrosine kinases (PTKs)(1). PTPs can be categorized into four families based on the amino …
tyrosine kinases (PTKs)(1). PTPs can be categorized into four families based on the amino …
SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation
N Wang, S Tan, M Wang, H Liu, S Han, Z Wu, J Ma… - bioRxiv, 2024 - biorxiv.org
The protein tyrosine phosphatase SHP-1 is a key negative regulator in cancer by
dephosphorylating multiple target molecules. Specially in the NFκB signaling, where …
dephosphorylating multiple target molecules. Specially in the NFκB signaling, where …
