Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …

Sarcomas are a group of malignant tumors originating from mesenchymal tissue with a variety
of cell subtypes. Despite several major treatment breakthroughs, standard treatment using …

Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth
factor receptor 2 (VEGFR-2). We conducted a single-arm, nonrandomized phase II study (…

Extraskeletal osteosarcoma (ESOS) is an extremely rare malignancy with poor prognosis,
accounting for 2–4% of all osteogenic sarcomas. The purpose of this study was to examine the …

At the recent 2022 American Society of Clinical Oncology (ASCO) annual meeting, the latest
progress was presented in clinical trials of various therapeutic modalities for adult soft tissue …

Background There is no standard treatment for stage IV soft tissue sarcoma (STS) after the
failure of Adriamycin-based chemotherapy. This phase II study (NCT03121846) assessed the …

Objective: To analyze the efficacy and safety of apatinib in the treatment of stage IV osteogenic
sarcoma after chemotherapy failure through a single-arm, prospective, and open clinical …

Objective: Sarcomas are a group of rare malignancies with various subtypes. Patients with
metastatic sarcoma who have failed traditional treatments can possibly achieve better …

Purpose This retrospective case-series study evaluated efficacy and safety of Endostar
combined with chemotherapy in the treatment of advanced bone and soft tissue sarcomas in …

Background Sarcoma is a highly heterogeneous malignancy with a poor prognosis. Although
chemotherapy and targeted therapy have improved the prognosis to some extent, the …